Adriana S . Dusso , Alex J . Brown and Eduardo Slatopolsky Vitamin
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چکیده
respective cells and vasculature, as well as to the control of body fluid volume and composition. It is published 12 times a year publishes original manuscripts on a broad range of subjects relating to the kidney, urinary tract, and their
منابع مشابه
Invited Review Vitamin D
Dusso, Adriana S., Alex J. Brown, and Eduardo Slatopolsky. Vitamin D. Am J Physiol Renal Physiol 289: F8–F28, 2005; doi:10.1152/ajprenal.00336.2004.—The vitamin D endocrine system plays an essential role in calcium homeostasis and bone metabolism, but research during the past two decades has revealed a diverse range of biological actions that include induction of cell differentiation, inhibitio...
متن کاملVitamin D.
The vitamin D endocrine systems plays a critical role in calcium and phosphate homeostasis. The active form of vitamin D, 1,25-dihydroxyvitamin D3[1,25(OH)2D3], binds with high affinity to a specific cellular receptor that acts as a ligand-activated transcription factor. The activated vitamin D receptor (VDR) dimerizes with another nuclear receptor, the retinoid X receptor (RXR), and the hetero...
متن کاملVitamin D analogues for secondary hyperparathyroidism.
Secondary hyperparathyroidism (2HPT), a common disorder in patients with chronic renal failure, develops in response to phosphate retention and low serum 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), calcitriol). Replacement therapy with calcitriol or its precursor 1alpha-hydroxyvitamin D(3) (1alphaOHD(3), alfacalcidol) often produces hypercalcaemia, especially when combined with calcium-based p...
متن کاملVitamin D receptor and analogs.
In chronic kidney disease (CKD), high circulating levels of parathyroid hormone (PTH) cause osteitis fibrosa, bone loss, and cardiovascular complications that increase morbidity and mortality. Impaired production of 1,25-dihydroxyvitamin D (calcitriol), the hormonal form of vitamin D, is a major contributor to the generation and maintenance of parathyroid hyperplasia and increased synthesis and...
متن کاملThe noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion.
OCT, a non-calcemic analogue of 1,25(OH)2D3 has been found to have a more potent activity than that of 1,25(OH)2D3 regarding cell differentiation and immunopotentiation activity, and to prolong the average life span of MRL/l mice. Recently, we found that OCT effectively suppressed the secretion and synthesis of PTH without inducing hypercalcemia. In primary cultures of bovine parathyroid cells,...
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تاریخ انتشار 2005